Castelmola (Sicilian: Castermula) is a comune (municipality) in the Province of Messina in the Italian region Sicily, located about 170 kilometres (110 mi) east of Palermo and about 40 kilometres (25 mi) southwest of Messina. As of 31 December 2004, it had a population of 1,107 and an area of 16.4 square kilometres (6.3 sq mi).Castelmola has ancient Greek origins. Situated above Taormina, it formerly served as its acropolis. In the last decades it has become a popular tourist destination. On Labour Day, which in Italy falls on 1 May, there is an annual music festival "Castelrock", held in the main square, which features live music performances by local musicians.
Castelmola was nominated as one of the most beautiful villages in Italy.
Castelmola borders the following municipalities: Gaggi, Letojanni, Mongiuffi Melia, Taormina.